A simple and repeatable model of subarachnoid hemorrhage in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 1096-1098, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-253524
ABSTRACT
<p><b>AIM</b>To build a simple and repeatable animal model of subarachnoid hemorrhage (SAH).</p><p><b>METHODS</b>SAH was produced by passing a nylon thread up through the right internal carotid artery and piercing a hole in the right anterior cerebral artery. At 12 h and 24 h after SAH operation, the rats were evaluated with rotarod test and the behavior scale (5-point scale).</p><p><b>RESULTS</b>The rats were trained through rotarod test and then randomly divided into three groups, including vehicle group treated with vehicle after SAH, nimodipine treated group (i.p. 0.25 mg x kg(-1), 5 min, 6 h, 12 h after SAH) and sham group. At the point of the perforation there was usually a capping clot. There was always blood in the basal cisterns with some spread over the hemisphere. After 12 h and 24 h of SAH operation, the time of rotarod test of rats decreased significantly and the rats had serious neurological deficit. Nimodipine could alleviate the neurological deficit after 24 h of SAH.</p><p><b>CONCLUSION</b>To present a simple and reliable model of SAH in the rats, which allows evaluating novel compounds and new drugs for treatment of SAH.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Hémorragie meningée
/
Comportement animal
/
Encéphale
/
Inhibiteurs des canaux calciques
/
Nimodipine
/
Circulation cérébrovasculaire
/
Reproductibilité des résultats
/
Rat Wistar
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2005
Type:
Article
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