Prodrug structural modifications of cyclovirobuxine D and their biological activity / 药学学报
Acta Pharmaceutica Sinica
; (12): 820-824, 2005.
Article
Dans Zh
| WPRIM
| ID: wpr-253561
Responsable en Bibliothèque :
WPRO
ABSTRACT
<p><b>AIM</b>To search for compounds for the treatment of cardiovascular diseases through prodrug structural modifications of cyclovirobuxine D, a single efficient composition distilled from Box plant in China, which was used to treat angina and myocardial infarction.</p><p><b>METHODS</b>According to prodrug design principle, a series of cyclovirobuxine D analogues were prepared, suc as succinate, phosphate and amino acid ester, and their biological activities were tested.</p><p><b>RESULTS</b>Seven new compounds were obtained and confirmed with 1H NMR, MS, and element analysis.</p><p><b>CONCLUSION</b>In pharmacology experiment, for treating arrhythmia induced by aconitine, succinate and amino acid ester of cyclovirobuxine D (I and VII) showed better activities than that of cyclovirobuxine D. The normal rhythm of the heart duration of I and VII were ( 11.53 +/- 7.62) min and (12.68 +/- 9.25) min, compared with 0.9% NaCl solution and cyclovirobuxine D, (2.36 +/- 1.68) min and (10.25 +/- 6.59) min (P < 0.01), respectively. Another pharmacology experiment, for treating arrhythmia induced by chloroform, the negative ratio of I and VII were 80% and 82%, compared with 0.9% NaCl solution and cyclovirobuxine D, 43% and 52% (P < 0.05), respectively. The difference between new compounds and cyclovirobuxine D was distinct.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Pharmacologie
/
Plantes médicinales
/
Troubles du rythme cardiaque
/
Aconitine
/
Médicaments issus de plantes chinoises
/
Promédicaments
/
Répartition aléatoire
/
Chimie
/
Chloroforme
/
Rat Sprague-Dawley
Limites du sujet:
Animals
langue:
Zh
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2005
Type:
Article