Stereoselective pharmacokinetics of tetrahydropalmatine in rats / 药学学报
Acta Pharmaceutica Sinica
;
(12): 746-749, 2005.
Article
Dans Chinois
| WPRIM
| ID: wpr-253576
ABSTRACT
<p><b>AIM</b>To investigate the stereoselective pharmacokinetic process of tetrahydropalmatine (THP) in rats.</p><p><b>METHODS</b>The concentrations of tetrahydropalmatine enantiomers in rat plasma were determined by coupled achiral and chiral HPLC method. The differences in plasma concentrations and pharmacokinetic parameters between the two enantiomers were compared by paired t-test.</p><p><b>RESULTS</b>The plasma levels of l-THP were always higher than those of d-THP in eight rats. There was significant difference between the main pharmacokinetic parameters of the two enantiomers.</p><p><b>CONCLUSION</b>Tetrahydropalmatine showed significant stereoselective pharmacokinetics in rats after an ig dose of the racemate.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Plantes médicinales
/
Stéréoisomérie
/
Alcaloïdes de type berbérine
/
Pharmacocinétique
/
Structure moléculaire
/
Chimie
/
Chromatographie en phase liquide à haute performance
/
Rat Sprague-Dawley
/
Aire sous la courbe
/
Corydalis
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2005
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS