Drug use and dosing in chronic kidney disease
Annals of the Academy of Medicine, Singapore
;
: 1095-1103, 2009.
Article
Dans Anglais
| WPRIM
| ID: wpr-253649
ABSTRACT
One of the most important drug-related problems in patients with chronic kidney disease (CKD) is medication dosing errors. Many medications and their metabolites are eliminated through the kidney. Thus, adequate renal function is important to avoid toxicity. Patients with renal impairment often have alterations in their pharmacokinetic and pharmacodynamic parameters. The clearance of drugs eliminated primarily by renal filtration is decreased by renal disease. Therefore, special consideration should be taken when these drugs are prescribed to patients with impaired renal function. Despite the importance of dosage adjustment in patients with CKD, such adjustments are sometimes ignored. Physicians and pharmacists can work together to accomplish safe drug prescribing. This task can be complex and require a stepwise approach to ensure effectiveness, minimise further damage and prevent drug nephrotoxicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ordonnances médicamenteuses
/
Normes de référence
/
Arbres de décision
/
Pharmacocinétique
/
Maladie chronique
/
Médicaments sur ordonnance
/
Débit de filtration glomérulaire
/
Maladies du rein
/
Métabolisme
Limites du sujet:
Humains
langue:
Anglais
Texte intégral:
Annals of the Academy of Medicine, Singapore
Année:
2009
Type:
Article
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