The effect of overdose fluoride on the proliferation and apoptosis of rat's incisor ameloblast / 中华口腔医学杂志
Chinese Journal of Stomatology
;
(12): 217-219, 2003.
Article
Dans Chinois
| WPRIM
| ID: wpr-253741
ABSTRACT
<p><b>OBJECTIVE</b>To observe the effect of overdose fluoride on the proliferation of rat's incisor ameloblast.</p><p><b>METHODS</b>20 Wistar rats were divided randomly into 2 groups Group I (Control); Group II 50 mg/L F(-) were given. After 8 weeks treatment, the AgNORs stain and TUNEL technique were applied to analyze the effect of fluoride on the proliferation and apoptosis of ameloblasts.</p><p><b>RESULTS</b>The imagination analysis results showed that proliferation of pre-secretion ameloblasts were inhibited in group II as compared with the control group (P < 0.001). There was significant increase of apoptosis with the trend of migration toward secretion stage.</p><p><b>CONCLUSION</b>The mechanism of fluorosis mottled enamel may be the effect of overdose fluoride with inhibits proliferation and induces apoptosis of ameloblasts resulting in dysfunction of secretion or absorption of enamel matrix proteins.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Répartition aléatoire
/
Rat Wistar
/
Apoptose
/
Émail dentaire
/
Prolifération cellulaire
/
Fluorures
/
Améloblastes
/
Incisive
/
Fluorose dentaire
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Chinese Journal of Stomatology
Année:
2003
Type:
Article
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