Primitive study of the cell lineage and Epstein-Barr virus infection in so called malignant histiocytosis with tissue microarray technique / 中华病理学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the cell lineage and Epstein-Barr virus infection in previously diagnosed cases of malignant histiocytosis (MH) with tissue microarray technique.</p><p><b>METHODS</b>Using tissue-chips, immunohistochemical staining, in situ hybridization and PCR to analyze 5 autopsy cases of MH.</p><p><b>RESULTS</b>(1) In all 5 cases, positive reactions of CD45RO, CD3 epsilon, TIA-1, Granzyme B were detected in the neoplastic cells, whereas negative reactions were found with CD30, CD20, CD56. (2) All cases revealed EBER1/2 positivity in neoplastic cells.</p><p><b>CONCLUSION</b>Previously diagnosed malignant histiocytosis is an EBV-associated aggressive NK/T cell lymphoma.</p>