Type IV secretion system in Helicobacter pylori: a new insight into pathogenicity / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 2138-2142, 2007.
Article
Dans Anglais
| WPRIM
| ID: wpr-255429
ABSTRACT
<p><b>OBJECTIVE</b>To review the research progress on Type IV secretion system (T4SS) in Helicobacter pylori.</p><p><b>DATA SOURCES</b>The data used in this review were identified by searching of PUBMED (1995 - 2007) online resources using the key terms 'Type IV secretion system' and 'Helicobacter pylori'.</p><p><b>STUDY SELECTION</b>Mainly original articles and critical reviews written by major pioneer investigators of this field were selected.</p><p><b>RESULTS</b>The research progress on T4SS in Helicobacter pylori was summarized. The structure and function was discussed.</p><p><b>CONCLUSIONS</b>T4SS is not only involved in toxin secretion and injection of virulence factors into eukaryotic host target cells, but also involved in horizontal DNA transfer to other bacteria and eukaryotic cells, through DNA uptake from or release into the extracellular milieu. It provides a new insight into the pathogenicity of Helicobacter pylori and a novel target for antimicrobials development. However, many challenges remain for us in understanding the biological role of T4SS in Helicobacter pylori.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Protéines bactériennes
/
Virulence
/
Famille multigénique
/
Helicobacter pylori
/
Transfert horizontal de gène
/
Protéines de liaison à l'ADN
/
Génétique
/
Métabolisme
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2007
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS