Clinicopathologic significance of chromosomal DNA sequence copy number aberrations in patients with colorectal carcinoma / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 355-359, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-255644
ABSTRACT
<p><b>OBJECTIVE</b>To analyze the correlation of DNA sequence copy number aberrations (DSCNAs)with clinicopathologic parameters in patients with colorectal cancer(CRC).</p><p><b>METHODS</b>Comparative genomic hybridization (CGH) method was used in analysis of 73 cases with CRC. Statistical analysis was performed using Stat View statistical software package(5.0).</p><p><b>RESULTS</b>Loss of 8pl2-pter and gain of 8q23-qter were linked to nodal metastasis, while loss of 18q12-qter and gain of 8q23-qter were associated with distant organ metastasis at diagnosis and (or) recurrence after surgery. Moreover, losses of 8pl2-pter and 18q12-qter and gain of 8q23-qter were associated significantly with unfavorable prognosis. Multivariate analysis revealed that loss of 18q12-qter was an independent prognostic marker.</p><p><b>CONCLUSION</b>Our findings indicate that genetic aberrations detected by CGH may predict outcome in patients with CRC, and may provide useful information for clinical treatment. Comparative genomic hybridization;</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pronostic
/
Tumeurs du rectum
/
Chromosomes humains de la paire 8
/
Chromosomes humains de la paire 18
/
ADN tumoral
/
Tumeurs du caecum
/
Génome humain
/
Analyse multifactorielle
/
Études de suivi
Type d'étude:
Étude observationnelle
/
Étude pronostique
Limites du sujet:
Adulte très âgé
/
Aged80
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2007
Type:
Article
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