Unique interactions between scorpion toxins and small conductance Ca(2+)-activated potassium channels / 生理学报
Acta Physiologica Sinica
;
(6): 255-260, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-255950
ABSTRACT
Small conductance Ca(2+)-activated potassium channels (SK channels) distributing in the nervous system play an important role in learning, memory and synaptic plasticity. Most pharmacological properties of them are determined by short-chain scorpion toxins. Different from most voltage-gated potassium channels and large-conductance Ca(2+)-activated potassium channels, SK channels are only inhibited by a small quantity of scorpion toxins. Recently, a novel peptide screener in the extracellular pore entryway of SK channels was considered as the structural basis of toxin selective recognition. In this review, we summarized the unique interactions between scorpion toxins and SK channels, which is crucial not only in deep-researching for physiological function of SK channels, but also in developing drugs for SK channel-related diseases.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Venins de scorpion
/
Scorpions
/
Chimie
/
Canaux potassiques calcium-dépendants de petite conductance
/
Mémoire
/
Plasticité neuronale
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta Physiologica Sinica
Année:
2015
Type:
Article
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