Shal-type (Kv4.x) potassium channel pore blockers from scorpion venoms / 生理学报
Acta Physiologica Sinica
;
(6): 248-254, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-255951
ABSTRACT
Voltage-gated potassium channels (Kv4.1, Kv4.2 and Kv4.3) encoded by the members of the KCND/Kv4 (Shal) channel family mediate the native, fast inactivating (A-type) K(+) current (IA) described both in heart and neurons. This IA current is specifically blocked by short scorpion toxins that belong to the α-KTx15 subfamily and which act as pore blockers, a different mode of action by comparison to spider toxins known as gating modifiers. This review summarizes our present chemical and pharmacological knowledge on the α-KTx15 toxins.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Venins de scorpion
/
Scorpions
/
Chimie
/
Inhibiteurs des canaux potassiques
/
Canaux potassiques Shal
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Acta Physiologica Sinica
Année:
2015
Type:
Article
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