Effect of qilong capsule on hemoreology in acute stress blood stasis rats / 中国中药杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the influence of Qilong capsule (QLC) on the hemoreology in acute stress blood stasis model rats.</p><p><b>METHOD</b>The model of acute stress blood stasis rats were induced by putting the rats into ice-water between hyodermic epinephrine twice of 1 mg x kg(-1). With the models, the effect of QLC on hemoreology such as whole blood viscosity, whole blood reduction viscosity, plasma viscosity, haematocrit (Hct), erythrocyte deformation and erythrocyte aggregation were observed.</p><p><b>RESULT</b>QLC 0.6, 0.3, 0.15 g x kg(-1) could significantly reduce the increase of whole blood viscosity at high-middle-low shear rate, reduce the whole blood reduction viscosity at middle-low shear rate, reduce Hct and erythrocyte aggregation, and increase the erythrocyte deformation in acute stress blood stasis rats (P < 0.05, P < 0.01, compared with vehicle). QLC 0.6, 0.3 g x kg(-1) could also reduce plasma viscosity (P < 0.05, P < 0.01, compared with vehicle).</p><p><b>CONCLUSION</b>QLC can significantly improve some indexes of hemoreology in acute stress blood stasis rats.</p>