Influence of Pueraria thomsonii on insulin resistance induced by dexamethasone / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 356-358, 2004.
Article
Dans Chinois
| WPRIM
| ID: wpr-256354
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the influence of Pueraria thomsonii on insulin resistance induced by dexamethasone.</p><p><b>METHOD</b>3T3-L1 adipocytes model of insulin resistance was made by dexamethasone and the change of glucose concentration in cell culture was determined after action of drugs. Rat animal model of insulin resistance was made by intramuscular dexamethasone (1 mg x kg(-1), every other day), and fasting blood glucose (FBG) and fasting serum insulin (FINS) were enamined, and at the end of the experiment, insulin sensitive index (ISI) and insulin resistance index (IRI) were calculated.</p><p><b>RESULT</b>P. thomsonii decreased the concentration of glucose in 3T3-L1 adipocytes culture significantly and improved the sensitivity of 3T3-L1 adipocytes to insulin. P. thomsonii improved the sensitivity of rats to insulin and diminished the fasting serum insulin and insulin resistance index.</p><p><b>CONCLUSION</b>P. thomsonii can significantly improve insulin resistance induced by dexamethasone.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Plantes médicinales
/
Sang
/
Glycémie
/
Insulinorésistance
/
Dexaméthasone
/
Médicaments issus de plantes chinoises
/
Chimie
/
Cellules 3T3
/
Rat Wistar
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2004
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS