Role of tumor necrosis factor-like weak inducer of apoptosis (TWEAK)/fibroblast growth factor-inducible 14 (Fn14) axis in rheumatic diseases / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 3898-3904, 2012.
Article
de En
| WPRIM
| ID: wpr-256621
Bibliothèque responsable:
WPRO
ABSTRACT
Tumor necrosis factor (TNF)-like weak inducer of apoptosis (TWEAK) is a member of the TNF superfamily of structurally related cytokines and is known to induce proliferation, migration, differentiation, apoptotic cell death, inflammation, and angiogenesis. These physiological processes are induced by the binding of TWEAK to fibroblast growth factor-inducible 14 (Fn14), a highly inducible cell-surface receptor that is linked to several intracellular signaling pathways, including the nuclear factor-κB (NF-κB) pathway. This review discusses the role of the TWEAK-Fn14 axis in several rheumatic diseases and the potential therapeutic benefits of modulation of the TWEAK-Fn14 pathway.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Physiologie
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Polyarthrite rhumatoïde
/
Sclérodermie systémique
/
Rhumatismes
/
Récepteurs aux facteurs de nécrose tumorale
/
Facteurs de nécrose tumorale
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Cytokine TWEAK
/
Récepteur TWEAK
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Lupus érythémateux disséminé
Limites du sujet:
Humans
langue:
En
Texte intégral:
Chinese Medical Journal
Année:
2012
Type:
Article