A case of severe hyponatremia induced by duloxetine and ziprasidone / 中华医学杂志(英文版)
Chinese Medical Journal
;
(24): 3750-3751, 2012.
Article
Dans Anglais
| WPRIM
| ID: wpr-256653
ABSTRACT
We report a case of severe hyponatremia related to duloxetine and ziprasidone. A 50-year-old woman on duloxetine and ziprasidone treatment for major depressive disorder developed polydipsia, polyuria, and two episodes of seizures, followed by admission to the emergency department on the 10th day of treatment. Laboratory investigations revealed elevated creatine kinase (CK) as well as hyponatremia, hypo-osmolality, and increased urine sodium. Syndrome of Inappropriate Antidiuretic Hormone (SIADH) was considered, although urine osmolality was not measured. Duloxetine and ziprasidone were discontinued and the CK gradually normalized after correction of hyponatremia. Clinicians should be aware of the possibility of antipsychotic-induced hyponatremia, particularly in patients with symptoms of polydipsia.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pipérazines
/
Thiazoles
/
Thiophènes
/
Neuroleptiques
/
Sang
/
Creatine kinase
/
Trouble dépressif majeur
/
Traitement médicamenteux
/
Chlorhydrate de duloxétine
/
Hyponatrémie
Limites du sujet:
Femelle
/
Humains
langue:
Anglais
Texte intégral:
Chinese Medical Journal
Année:
2012
Type:
Article
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