Lipopolysaccharide affects male reproductive function through Toll-like receptors / 中华男科学杂志
National Journal of Andrology
;
(12): 163-168, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-256942
ABSTRACT
Reproductive tract infection is one of the factors of male infertility, but the mechanisms responsible are hitherto poorly defined. Recent studies show that one of the microbial pattern-recognition receptors, Toll-like receptor (TLR) signaling pathway, plays a critical role in inflammation-induced male infertility. Lipopolysaccharide (LPS), a major component in the cell wall of gram-negative bacteria, could induce inflammatory response through TLRs. A large number of researches suggest that TLRs express widely in the male reproductive tract and LPS-induced inflammatory reaction through TLRs may affect male fertility. This article presents an overview on how LPS-induced inflammation through TLRs affects male fertility in terms of its influence on the testis, epididymis and sperm quality.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Lipopolysaccharides
/
Récepteurs de type Toll
/
Maladies de l'appareil génital mâle
/
Bactéries à Gram négatif
/
Infertilité masculine
/
Inflammation
/
Métabolisme
Limites du sujet:
Humains
/
Mâle
langue:
Chinois
Texte intégral:
National Journal of Andrology
Année:
2013
Type:
Article
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