Study on the distribution of nodularin in tissues and cell level in mice / 中华预防医学杂志

ABSTRACT

<p><b>OBJECTIVES</b>To study the tissue distribution of nodularin in mice and the cellular location of nodularin in the target organs.</p><p><b>METHODS</b>The nodularin was labeled with radioactive isotope (125)I and then was given to mice via oral, intraperitoneal and intravenous administration. The distribution of nodularin in target organs and the cellular location of nodularin were studied by radioisotope and autoradiography techniques.</p><p><b>RESULTS</b>The radioisotope study results showed that nodularin was mainly distributed in the kidney and liver in mice. Further autoradiography study indicated that nodularin was distributed in the renal cell nuclei and liver cell nuclei.</p><p><b>CONCLUSION</b>The kidney and liver are the two main target organs for nodularin in mice.</p>