The role of human herpesvirus-8 infection in the pathogenesis of multiple myeloma / 中国实验血液学杂志
Journal of Experimental Hematology
;
(6): 81-84, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-258063
ABSTRACT
Multiple myeloma is a B-cell neoplasm characterized by abnormal proliferation and accumulation of monoclonal plasma cells in the bone marrow. Recently some laboratories have detected human herpesvirus-8 (HHV-8) DNA sequences in bone marrow dendritic cells from myeloma patients. It has been suggested that the cytokines expressed by HHV-8 gene, such as vIRF, vIL-8R and vIL-6, may play a role in the pathogenesis of multiple myeloma. However, the majority of European investigators failed to find evidence to confirm this observation. It remains unclear whether HHV-8 is consequentially associated with myeloma or only a regional opportunistic infection. Controversy still focuses on the role of specific HHV-8 strains involved in pathogenesis of multiple myeloma and causality between the
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Virologie
/
Cellules dendritiques
/
Études séroépidémiologiques
/
Épidémiologie
/
Cytokines
/
Infections à Herpesviridae
/
Herpèsvirus humain de type 8
/
Allergie et immunologie
/
Métabolisme
Type d'étude:
Etude d'étiologie
Limites du sujet:
Humains
langue:
Chinois
Texte intégral:
Journal of Experimental Hematology
Année:
2002
Type:
Article
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