Prognostic factors for 72 patients with osteosarcoma of the extremity treated with neoadjuvant chemotherapy / 中华外科杂志

ABSTRACT

<p><b>OBJECTIVE</b>To determine the prognostic factors that influence survival of patients with non-metastatic, high-grade osteosarcoma of the extremities.</p><p><b>METHODS</b>The data of 72 patients treated between June 2003 and June 2007, was retrospectively evaluated in relation to many factors including gender, age, etc.</p><p><b>RESULTS</b>Tumor necrosis was significantly related to gender, tumor volume change, tumor margin and T2 signal intensity of the extraosseous component of bone sarcomas. Multivariate analysis, tumor necrosis was only related to tumor volume change. Upon multivariate analysis, good histologic response was related to the outcome of patients.</p><p><b>CONCLUSIONS</b>Event free survival is related to the tumor necrosis, the level of alkaline phosphatase and the change of T2 signal of the extraosseous component. Tumor necrosis is related to the volume change after preoperative chemotherapy. These factors must be considered when deciding risk-adapted treatments for patients with osteosarcoma.</p>