Association of SelS mRNA expression in omental adipose tissue with Homa-IR and serum amyloid A in patients with type 2 diabetes mellitus / 中华医学杂志(英文版)
Chinese Medical Journal
; (24): 1165-1168, 2008.
Article
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| ID: wpr-258512
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ABSTRACT
<p><b>BACKGROUND</b>Tanis was reported as a putative receptor for serum amyloid A (SAA) involving glucose regulated protein in insulin regulated resistance. It was found to be dysregulated in diabetic rats (Psammomys obesus, Israeli sand rat) and its homologue for humans is SelS/AD-015. The present study analyzed mRNA expression of SelS in omental adipose tissue biopsies from patients with type 2 diabetes mellitus (T2DM), and age- and weight-matched nondiabetic patients, the relationship of SelS mRNA with Homa-IR and serum SAA level.</p><p><b>METHODS</b>Human omental adipose tissues from ten cases of type 2 diabetic patients and twelve cases of nondiabetic individuals were analyzed for the expression level of SelS mRNA by semiquantitative polymerase chain reaction (PCR), Homa-IR estimated by standard formula and SAA level by enzyme-linked immunosorbent assay (ELISA).</p><p><b>RESULTS</b>SelS mRNA expression, Homa-IR and serum SAA were higher in T2DM sufferers than in nondiabetic control group. SelS mRNA level was positively correlated with Homa-IR and SAA level in each group.</p><p><b>CONCLUSIONS</b>SelS protein may be involved in insulin resistance in Chinese with T2DM by acting as the SAA receptor, thus playing an important role in the development of T2DM and atherosclerosis.</p>
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Omentum
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Protéine amyloïde A sérique
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Insulinorésistance
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ARN messager
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Données de séquences moléculaires
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Séquence nucléotidique
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Tissu adipeux
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Diabète de type 2
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Sélénoprotéines
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Génétique
Limites du sujet:
Adult
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Aged
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Female
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Humans
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Male
langue:
En
Texte intégral:
Chinese Medical Journal
Année:
2008
Type:
Article