Progress in endogenous cardioprotection induced by ischemic postconditioning / 生理学报
Acta Physiologica Sinica
;
(6): 628-634, 2007.
Article
Dans Chinois
| WPRIM
| ID: wpr-258613
ABSTRACT
Restoration of blood flow is the definitive therapy to salvage myocardium following ischemic injury. Sudden restoration of blood flow to the ischemic myocardium may, however, also cause reperfusion injury. Therefore, to prevent such ischemia/reperfusion (I/R) injury, one strategy could be to evoke endogenous myocardial protective mechanisms. Ischemic preconditioning (IPC) and postconditioning (I-postC) are endogenous protective mechanisms capable of protecting the myocardium from myocardial infarction, stunning, and ventricular arrhythmia induced by I/R injury. The mechanisms involve induction of triggers, activation of signaling pathways, and end-effectors, which attenuate generation of free radicals and calcium overload induced by I/R. The fact that I-postC can be applied after a prolonged period of ischemia offers a novel approach to myocardial protection. This article mainly reviews the cardioprotection, mechanisms, and application to clinical cardiology of I-postC.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Troubles du rythme cardiaque
/
Malformations
/
Lésion de reperfusion myocardique
/
Lésion d'ischémie-reperfusion
/
Transduction du signal
/
Syndrome de Brugada
/
Postconditionnement ischémique
/
Trouble de la conduction cardiaque
/
Système de conduction du coeur
/
Infarctus du myocarde
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Physiologica Sinica
Année:
2007
Type:
Article
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