Effects of Exogenous Carbon Monoxide Releasing Molecules on the Development of Zebrafish Embryos and Larvae / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 453-456, 2016.
Article
Dans Anglais
| WPRIM
| ID: wpr-258800
ABSTRACT
The use of exogenous carbon monoxide releasing molecules (CORMs) provides promise for clinical application; however, the hazard potential of CORMs in vivo remains poorly understood. The developmental toxicity of CORM-3 was investigated by exposure to concentrations ranging from 6.25 to 400 μmol/L during 4-144 h post fertilization. Toxicity endpoints of mortality, spontaneous movement, heart rate, hatching rate, malformation, body length, and larval behavior were measured. CORM-3 disrupted the progression of zebrafish larval development at concentrations exceeding 50 μmol/L, resulting in embryonic developmental toxicity.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Composés organométalliques
/
Pharmacologie
/
Danio zébré
/
Monoxyde de carbone
/
Cardiotoniques
/
Embryologie
/
Développement embryonnaire
/
Relation dose-effet des médicaments
/
Embryon non mammalien
/
Toxicité
Limites du sujet:
Animaux
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2016
Type:
Article
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