Fluoride Exposure, Follicle Stimulating Hormone Receptor Gene Polymorphism and Hypothalamus-pituitary-ovarian Axis Hormones in Chinese Women / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 696-700, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-258887
ABSTRACT
The effects of fluoride exposure on the functions of reproductive and endocrine systems have attracted widespread attention in academic circle nowadays. However, it is unclear whether the gene-environment interaction may modify the secretion and activity of hypothalamus-pituitary- ovarian (HPO) axis hormones. Thus, the aim of this study was to explore the influence of fluoride exposure and follicle stimulating hormone receptor (FSHR) gene polymorphism on reproductive hormones in Chinese women. A cross sectional study was conducted in seven villages of Henan Province, China during 2010-2011. A total of 679 women aged 18-48 years were recruited through cluster sampling and divided into three groups, i.e. endemic fluorosis group (EFG), defluoridation project group (DFPG), and control group (CG) based on the local fluoride concentration in drinking water. The serum levels of gonadotropin releasing hormone (GnRH), follicle stimulating hormone (FSH), luteinizing hormone (LH), and estradiol (E2) were determined respectively and the FSHR polymorphism was detected by real time PCR assay. The results provided the preliminary evidence indicating the gene-environment interaction on HPO axis hormones in women.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Ovaire
/
Physiologie
/
Hypophyse
/
Pollution par la fumée de tabac
/
Urine
/
Sang
/
Récepteur FSH
/
Hormone lutéinisante
/
Chine
/
Enrichissement en fluor
Type d'étude:
Étude observationnelle
/
Étude de prévalence
/
Facteurs de risque
Limites du sujet:
Adolescent
/
Adulte
/
Femelle
/
Humains
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2015
Type:
Article
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