Assessing Adverse Effects of Aroclor 1254 on Perinatally Exposed Rat Offspring / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 687-690, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-258889
ABSTRACT
To assess the neurotoxic effects and redox responses of Aroclor 1254 (A1254) on perinatally exposed rat offspring, A1254 was administered by gavage from gestational day (GD) 6 to postnatal day (PND) 21. Neurobehavioral development, antioxidant enzyme activities, lipid peroxidation (LPO), nitric oxide (NO), and NO synthase (NOS) levels were analyzed in the offspring. Neurobehavioral development analysis revealed delayed appearance of the righting reflex, negative geotaxis, and cliff drop test responses in A1254 exposed group. Developmental A1254 exposure also caused oxidative stress in the brain of PND 22 offspring via reductions in the activity of SOD and GSH-Px, and by promoting a rise in the levels of NO and NOS.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Effets différés de l'exposition prénatale à des facteurs de risque
/
Superoxide dismutase
/
Vieillissement
/
Peroxydation lipidique
/
Répartition aléatoire
/
Cortex cérébral
/
Stress oxydatif
/
Nitric oxide synthase
/
Toxicité
/
Glutathione peroxidase
Limites du sujet:
Animaux
/
Grossesse
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2015
Type:
Article
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