Pathogenesis of post-transplantation diabetes mellitus in 40 renal transplantation recipients / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 292-295, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-259025
ABSTRACT
<p><b>OBJECTIVE</b>To explore pathogenesis of post-transplantation diabetes mellitus (PTDM) in renal transplantation recipients.</p><p><b>METHODS</b>A total of 40 renal transplantation recipients were divided into three groups based on oral glucose tolerance test results:
normal glucose tolerance (NGT) group (n = 10), impaired fasting glycaemia + impaired glucose tolerance (IFG + IGT) group (n = 16), and PTDM group (n = 14). Insulin resistance (IR) and beta cell function were assessed by homeostasis model.</p><p><b>RESULTS</b>The differences of the immunosuppressive agents used in these groups were not statistically significant (P > 0.05). Compared with NGT group, insulin area under curve and homeostasis model assessment-insulin resistance index were significantly higher in IGT + IFG group and PTDM group (P < 0.05). Compared with NGT group and IGT + IPG group, insulin secretion index at 30 min and homeostasis model assessment-insulin secretion index were significantly lower in PTDM group (P < 0.05).</p><p><b>CONCLUSION</b>Insulin resistance and beta-cell dysfunction may play a key role in the pathogenesis of PTDM.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Complications postopératoires
/
Insulinorésistance
/
Études rétrospectives
/
Transplantation rénale
/
Diabète
/
Cellules à insuline
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
Limites du sujet:
Adulte
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2009
Type:
Article
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