Clinical characteristics of patients with juvenile localized scleroderma / 中国医学科学院学报

ABSTRACT

<p><b>OBJECTIVE</b>To investigate the clinical characteristics of juvenile localized scleroderma (JLS).</p><p><b>METHODS</b>The clinical data of 100 outpatients with JLS who were admitted to PUMC Hospital from 2000 to 2008 were retrospectively analyzed.</p><p><b>RESULTS</b>Of a total of 100 cases, 51 (51%) were confirmed as linear scleroderma, 26 (26%) as plaque morphea, 26 (26%) as deep morphea, 12 (12%) as generalized morphea, and 15 (15%) as a mixed subtype. Nine patients (9%) had family histories of rheumatic or autoimmune diseases, while 16 (16%) might be triggered by unknown factors. Totally 84 patients underwent antinuclear antibody tests and 38 patients (45.2%) had positive results.</p><p><b>CONCLUSIONS</b>Linear scleroderma are the most frequent subtype of JLS. Localized scleroderma may be associated with some autoimmune-related causes.</p>