Effect of neuronal differentiation induced by nerve growth factor on the tolerance-dosage of ultraviolet radiation of PC12 cells / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 24-26, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-259083
ABSTRACT
<p><b>OBJECTIVE</b>To evaluate the effect of neuronal differentiation induced by nerve growth factor (NGF) on the tolerance-dosage of ultraviolet radiation of PC12 Cells.</p><p><b>METHODS</b>Neuron-differentiated PC12 cells and untreated PC12 cells were exposed to different ultraviolet radiation dosage of 10, 30, 60, 80, 100, and 200 mJ/cm2. Cell survival rates were determined by MTT assay.</p><p><b>RESULTS</b>Neuron-differentiated PC12 cells had increased tolerance dose to ultraviolet radiation with noticeable apoptosis at the radiation dose of 100 mJ/cm2 in contrast to 30 mJ/cm2 for normal PC12 cells.</p><p><b>CONCLUSION</b>Neuronal differentiation exerts the effect of increasing the tolerance dose of PC12 cells to ultraviolet radiation.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Effets des rayonnements
/
Rayons ultraviolets
/
Différenciation cellulaire
/
Transformation cellulaire néoplasique
/
Cellules PC12
/
Facteur de croissance nerveuse
/
Biologie cellulaire
/
Relation dose-effet des rayonnements
/
Neurones
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2009
Type:
Article
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