Expression of prostate stem cell antigen and Claudin-4 in human pancreatic carcinoma / 中国医学科学院学报
Acta Academiae Medicinae Sinicae
;
(6): 728-731, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-259093
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expressions of prostate stem cell antigen (PSCA) and Claudin-4 in human pancreatic carcinoma and to discuss its role in the ontogenesis of pancreatic cancer.</p><p><b>METHODS</b>Pancreatic carcinoma tissue microarray was constructed, containing 100 cores of 10 normal adult pancreas tissues, 12 chronic pancreatitis tissues, and 78 pancreatic carcinomas. The expressions of PSCA and Claudin-4 were detected using immunohistochemical method and the relationship between PSCA and Claudin-4 and the pancreatic carcinoma was analyzed.</p><p><b>RESULTS</b>The positive expression rates of PSCA and Claudin-4 protein in pancreatic carcinoma were 79. % and 88. % respectively. PSCA and Claudin-4 staining were more intense in malignant cells than in chronic pancreatic tissues and normal adult pancreas tissues. No evidence was found for an association between expressions of PSCA and Claudin-4 and other variables, including gender, age at surgery, and tumor grade.</p><p><b>CONCLUSIONS</b>The expressions of PSCA and Claudin-4 are related to the pancreatic carcinomas. PSCA and Claudin-4 play a role in the development of pancreatic cancer, but PSCA and Claudin-4 are not correlated with the clinical pathology of tumor.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Tumeurs du pancréas
/
Anatomopathologie
/
Glycoprotéines membranaires
/
Carcinomes
/
Régulation de l'expression des gènes tumoraux
/
Régulation positive
/
Protéines liées au GPI
/
Claudine-4
/
Génétique
/
Protéines membranaires
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Acta Academiae Medicinae Sinicae
Année:
2008
Type:
Article
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