Expression and clinical significance of 14-3-3 sigma and heat shock protein 27 in colorectal cancer / 中华胃肠外科杂志
Chinese Journal of Gastrointestinal Surgery
;
(12): 213-215, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-259306
ABSTRACT
<p><b>OBJECTIVE</b>To investigate the expression of 14-3-3 sigma and heat shock protein 27 (HSP27) in colorectal carcinoma(CRC) tissue and its clinical significance.</p><p><b>METHODS</b>The expression of 14-3-3 sigma and HSP27 was detected by immunohistochemical staining in 50 pathologically verified CRC cases. The association of clinical data with 14-3-3 sigma and HSP27 expression was examined.</p><p><b>RESULTS</b>The positive expression rate of 14-3-3 sigma was 10% in normal control mucosa and 58% in CRC tissue (P<0.01). The positive expression rate of HSP27 was 16% in normal control mucosa and 54% in CRC tissue (P<0.01). No correlation between 14-3-3 sigma and HSP27 expression was found in CRC tissue (P>0.05). The expression of 14-3-3 sigma was associated with patient age, tumor diameter and lymph node metastasis (LNM) (P<0.05), but not with gender, tumor differentiation or serous membrane invasion (P>0.05). The expression of HSP27 was associated with LNM (P<0.05), but not with gender, age, differentiation, tumor diameter or serous membrane invasion (P>0.05).</p><p><b>CONCLUSION</b>The abnormal expression of 14-3-3 sigma and HSP27 is significantly associated with LNM in CRC.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Tumeurs colorectales
/
Marqueurs biologiques tumoraux
/
Protéines 14-3-3
/
Exonucleases
/
Exoribonucleases
/
Protéines du choc thermique HSP27
/
Métastase lymphatique
/
Métabolisme
/
Protéines tumorales
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Gastrointestinal Surgery
Année:
2010
Type:
Article
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