Sphingosine kinase 1 and tumor / 药学学报
Acta Pharmaceutica Sinica
;
(12): 971-978, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-259521
ABSTRACT
Sphingolipids as an important regulator play a critical role in the cell biological functions. Among them, ceramide (Cer) and sphingosine (Sph) induce apoptosis and inhibit cell proliferation; on the contrary sphingosine 1-phosphate (S1P) promotes cell survival and proliferation. The balance between ceramide/sphingosine and S1P forms a so-called "sphingolipid-rheostat", which decides the cell fate. Sphingosine kinases, which catalyze the phosphorylation of sphingosine to S1P, are critical regulators of this balance. Here, we review the role of sphingosine kinase 1 (SphK1) in regulating fundamental biological processes and tumorigenesis and the potential of SphK1 as a new target for cancer therapeutics.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Phosphorylation
/
Sphingosine
/
Thiazoles
/
Lysophospholipides
/
Mouvement cellulaire
/
Céramides
/
Apoptose
/
Phosphotransferases (Alcohol Group Acceptor)
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
Acta Pharmaceutica Sinica
Année:
2013
Type:
Article
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