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Cytogenetic characteristics of 163 children with acute lymphoblastic leukemia / 中国实验血液学杂志
Journal of Experimental Hematology ; (6): 312-317, 2015.
Article Dans Chinois | WPRIM | ID: wpr-259593
ABSTRACT
<p><b>OBJECTIVE</b>To further understand the cytogenetic characteristics of pediatric acute lymphoblastic leukemia (ALL).</p><p><b>METHODS</b>Cytogenetic abnormalities of 163 children with newly diagnosed ALL (0-17 years of age) were evaluated by conventional cytogenetic analysis and fluorescent in situ hybridization findings.</p><p><b>RESULTS</b>Chromosome abnormalities were detected in 87.7% of patients (143/163). The ploidy levels most frequently observed among ALL patients were high hyperdiploidy (51-67 chromosomes) (45 cases, 27.6%), Chromosomes X and 21 were gained in 100% of these cases. The most common genetic alterations were t(12;21)/ETV6/RUNX1 (26 cases, 16.0%), followed by t(1;19)/TCF3/PBX1 (13 patients, 8.0%), t(4;11)/MLL rearrangement and t(8;14) IGH/MYC (6 cases, 3.7%), t(9;22)/BCR/ABL(2 cases, 1.2%), and iAMP21 (1 patient, 0.6%). The no-classical structural abnormalities included dup(1q) in 20.2%, del(6q) and del(9p) in 10.4%, del(12p) in 12.9% and del(13q) in 5.5%. The incidences of t(12;21), t(1;19), t(9;22) and high hyperdiploidy were consistent with reports in Western children (P>0.25). The incidence of (9;22) seemed to be much lower in our study than that in Korea (1.5% vs 9.5%, P<0.005).</p><p><b>CONCLUSION</b>Cytogenetic findings of childhood ALL patients are similar to that of Western countries, it seems no more adverse risk factors.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Aberrations des chromosomes / Protéines de fusion bcr-abl / Hybridation fluorescente in situ / Maladies chromosomiques / Analyse cytogénétique / Leucémie-lymphome lymphoblastique à précurseurs B et T Type d'étude: Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Humains / Bébé langue: Chinois Texte intégral: Journal of Experimental Hematology Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Aberrations des chromosomes / Protéines de fusion bcr-abl / Hybridation fluorescente in situ / Maladies chromosomiques / Analyse cytogénétique / Leucémie-lymphome lymphoblastique à précurseurs B et T Type d'étude: Facteurs de risque Limites du sujet: Adolescent / Enfant / Enfant d'âge préscolaire / Humains / Bébé langue: Chinois Texte intégral: Journal of Experimental Hematology Année: 2015 Type: Article