Research on optimization of polymerization process of human placenta hemoglobin / 生物医学工程学杂志
Journal of Biomedical Engineering
;
(6): 1336-1349, 2013.
Article
Dans Chinois
| WPRIM
| ID: wpr-259714
ABSTRACT
Five influencing factors of the polymerization process of glutaraldehyde with hemoglobin were studied in cluding the approach of feeding glutaraldehyde, hemoglobin concentration, the molar ratio of glutaraldehyde and hemoglobin, reaction time and temperature, in order to reduce the average molecular weight and to improve the effective polymerization ratio. The results showed that the optimal process reduced the average molecular weight of hemoglobin based oxygen carriers (HBOCs) from (350.20 +/- 35.45)kD to (158.60 +/- 8.70)kD and improved the effective polymerization ratio from 53.27% +/- 4.95% to 69.50% +/- 3.70%. When the experiments expanded 30 folds, the results of the effective polymerization ratio and the average molecular weight mentioned above could be achieved.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oxygène
/
Placenta
/
Hémoglobines
/
Chimie
/
Glutaraldéhyde
/
Polymérisation
/
Masse moléculaire
Limites du sujet:
Femelle
/
Humains
/
Grossesse
langue:
Chinois
Texte intégral:
Journal of Biomedical Engineering
Année:
2013
Type:
Article
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