IL-24 Expression at Maternal-fetal Interface and Its Roles in Trophoblast Invasion / 华中科技大学学报(医学)(英德文版)
Journal of Huazhong University of Science and Technology (Medical Sciences)
; (6): 456-459, 2008.
Article
Dans Zh
| WPRIM
| ID: wpr-260136
Responsable en Bibliothèque :
WPRO
ABSTRACT
In this study, the expression of IL-24 at maternal-fetal interface and the roles in extravillous trophoblast (the TEV-1 cell line) invasion were examined. Immunohistochemistry was used to detect the expression of IL-24 in villi and decidual tissue. The proliferation of TEV-1 cells under the effect of IL-24 was measured by MTT assay. The invasiveness of TEV-1 cells under the effect of recombinant IL-24 (rhIL-24) was examined by transwell system. Immunohistochemical detection showed that IL-24 was expressed in the villi and decidual tissue, and distributed in villous column,trophoblasts, stroma and blood vessels. The proliferation of TEV-1 cells was not inhibited by rhIL-24of various concentrations. The examination of invasion in vitro showed that rhIL-24 could inhibit the invasion of TEV-1 cells in a concentration-dependent manner. The results suggested IL-24 could inhibit the invasion of TEV-1 cells. Therefore, IL-24 produced by maternal-fetal interface in human first trimester pregnancy may influence the invasion of trophoblasts and is involved in normal pregnancy.
Texte intégral:
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Indice:
WPRIM
langue:
Zh
Texte intégral:
Journal of Huazhong University of Science and Technology (Medical Sciences)
Année:
2008
Type:
Article