Functional Bax polymorphism associated with lung cancer susceptibility / 中华肿瘤杂志
Chinese Journal of Oncology
;
(12): 324-327, 2010.
Article
Dans Chinois
| WPRIM
| ID: wpr-260406
ABSTRACT
<p><b>OBJECTIVE</b>The Bcl-2 associated X protein (Bax), belonging to the Bcl-2 family, plays a pivotal role in mitochondria-dependent apoptosis. The aims of this study are to revalidate the functional significance of Bax G(-248)A polymorphism, and investigate its association with lung cancer risk in Chinese population.</p><p><b>METHODS</b>The biological function of Bax G(-248)A was tested by luciferase assays, and its effects on lung cancer risk was determined by case-control analysis of 989 patients with lung cancer and 990 controls.</p><p><b>RESULTS</b>Bax -248A allele exhibited significantly higher transcriptional activity compared with G allele. The Bax-248A allele carriers yielded a significantly decreased risk of lung cancer, compared with -248G allele carriers (OR = 0.68, 95% CI = 0.48 approximately 0.90, P = 0.01). Furthermore, a significant gene-smoking interaction between Bax G(-248)A polymorphism and smoking existed among the light smokers.</p><p><b>CONCLUSION</b>Bax G(-248)A polymorphism is associated with lung cancer susceptibility in Chinese population.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Polymorphisme de restriction
/
Carcinome épidermoïde
/
Adénocarcinome
/
Fumer
/
Études cas-témoins
/
Odds ratio
/
Facteurs de risque
/
Prédisposition génétique à une maladie
/
Lignée cellulaire tumorale
Type d'étude:
Etude d'étiologie
/
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Adulte
/
Adulte très âgé
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
Chinese Journal of Oncology
Année:
2010
Type:
Article
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