Research advances in gene polymorphisms in biological pathways of drugs for asthma / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics
;
(12): 567-573, 2016.
Article
Dans Chinois
| WPRIM
| ID: wpr-261189
ABSTRACT
The studies on gene polymorphisms in biological pathways of the drugs for the treatment of asthma refer to the studies in which pharmacogenetic methods, such as genome-wide association studies, candidate gene studies, genome sequencing, admixture mapping analysis, and linkage disequilibrium, are used to identify, determine, and repeatedly validate the effect of one or more single nucleotide polymorphisms on the efficacy of drugs. This can provide therapeutic strategies with optimal benefits, least side effects, and lowest costs to patients with asthma, and thus realize individualized medicine. The common drugs for asthma are β2 receptor agonists, glucocorticoids, and leukotriene modifiers. This article reviews the research achievements in polymorphisms in biological pathways of the common drugs for asthma, hoping to provide guidance for pharmacogenetic studies on asthma in future and realize individualized medicine for patients with asthma soon.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacogénétique
/
Asthme
/
Leucotriènes
/
Polymorphisme de nucléotide simple
/
Utilisations thérapeutiques
/
Traitement médicamenteux
/
Voies et réseaux métaboliques
/
Médecine de précision
/
Agonistes des récepteurs béta-2 adrénergiques
/
Génétique
Type d'étude:
Guide de pratique
langue:
Chinois
Texte intégral:
Chinese Journal of Contemporary Pediatrics
Année:
2016
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS