Your browser doesn't support javascript.
loading
Levels of surfactant proteins A and D in bronchoalveolar lavage fluid of children with pneumonia and their relationships with clinical characteristics / 中国当代儿科杂志
Chinese Journal of Contemporary Pediatrics ; (12): 386-390, 2016.
Article Dans Chinois | WPRIM | ID: wpr-261223
ABSTRACT
<p><b>OBJECTIVE</b>To observe the levels of pulmonary surfactant proteins A and D (SP-A, SP-D) in bronchoalveolar lavage fluid (BALF) of children with pneumonia, and to explore their relationships with clinical characteristics.</p><p><b>METHODS</b>Thirty-five children with pneumonia were enrolled in this study. Differential cell counts were obtained by Countstar counting board. The levels of SP-A and SP-D in BALF were detected using ELISA.</p><p><b>RESULTS</b>In children with pneumonia, SP-D levels were significantly higher than SP-A levels (P<0.001). SP-D levels were negatively correlated with the neutrophil percentage in BALF (r(s)=-0.5255, P<0.01). SP-D levels in BALF in children with increased blood C-reactive protein levels (>8 mg/L) were significantly lower than in those with a normal level of C-reactive protein (P<0.05). Compared with those in children without wheezing, SP-D levels in children with wheezing were significantly lower (P<0.01). There was no correlation between SP-A levels and clinical characteristics.</p><p><b>CONCLUSIONS</b>SP-D levels in BALF are significantly higher than SP-A levels, and have a certain correlation with clinical characteristics in children with pneumonia. As a protective factor, SP-D plays a more important role than SP-A in regulating the immune and inflammatory responses.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pneumopathie infectieuse / Protéine C-réactive / Test ELISA / Liquide de lavage bronchoalvéolaire / Chimie / Protéine A associée au surfactant pulmonaire / Protéine D associée au surfactant pulmonaire / Métabolisme Limites du sujet: Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2016 Type: Article

Documents relatifs à ce sujet

MEDLINE

...
LILACS

LIS

Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pneumopathie infectieuse / Protéine C-réactive / Test ELISA / Liquide de lavage bronchoalvéolaire / Chimie / Protéine A associée au surfactant pulmonaire / Protéine D associée au surfactant pulmonaire / Métabolisme Limites du sujet: Enfant / Enfant d'âge préscolaire / Femelle / Humains / Bébé / Mâle langue: Chinois Texte intégral: Chinese Journal of Contemporary Pediatrics Année: 2016 Type: Article