Allogeneic bone marrow transplantation for the treatment of Bruton disease / 中华血液学杂志

ABSTRACT

<p><b>OBJECTIVE</b>To explore the efficacy of allogeneic bone marrow transplantation (allo-BMT) for the treatment of Bruton disease.</p><p><b>METHODS</b>HLA-matched sibling bone marrow transplantation was performed for the treatment of 2 cases of X-linked agammaglobulinemia. One of them received allo-BMT twice.</p><p><b>RESULTS</b>Recovery of hematopoiesis was gained at day 20 and day 13 after allo-BMT in the two cases respectively. Serum immunoglobin rose gradually to normal level in three months. Their humoral immuno-system was reconstituted and life quality improved. These two patients are still in disease-free survival for 13 and 2 years respectively. There was no serious graft-versus-host-disease.</p><p><b>CONCLUSION</b>Stem cell transplantation is a choice for the treatment of Bruton disease.</p>