Effect of Cynomorium songaricum polysaccharide on telomere length in blood and brain of D-galactose-induced senescence mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1257-1260, 2009.
Article
Dans Chinois
| WPRIM
| ID: wpr-263055
ABSTRACT
<p><b>OBJECTIVE</b>To study the effects of Cynomorium songaricum polysaccharide (CSP) on telomere length in blood and brain tissues of aged mice in order to provide some evidence for CSP's development and applying in the clinical uses.</p><p><b>METHOD</b>Kunming mice were intraperitoneal injected D-galactose (500 mg x kg(-1) x d(-1)) to make the aging models, and different dosages of CSP (20, 40, 80 mg x kg(-1)) were given by gavage for 56 days. The average length of telomere was determined by real-time fluorescence quantitative PCR.</p><p><b>RESULT</b>The relative T/S ratio of the group high and middle dosages of CSP in blood were 1.64 +/- 0.36 and 1.33 +/0.28, respectively, and higher than that of the group of senescence 1.01 +/- 0.13 (P < 0.01). Values of the group of high, middle, and low dosages of CSP in brain tissues were 3.34 +/- 0.58, 2.30 +/- 0. 75 and 1.55 +/- 0.58, respectively, and significantly higher than that of the group of senescence 1.04 +/- 0.33 (P < 0.01).</p><p><b>CONCLUSION</b>CSP can exert the anti-aging effects by increase telomere length f senescence mice.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Physiologie
/
Polyosides
/
Encéphale
/
Vieillissement
/
Médicaments issus de plantes chinoises
/
Chimie
/
Télomère
/
Vieillissement de la cellule
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2009
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS