Heuristic algorithm for off-lattice protein folding problem / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
;
(12): 7-12, 2006.
Article
Dans Anglais
| WPRIM
| ID: wpr-263231
ABSTRACT
Enlightened by the law of interactions among objects in the physical world, we propose a heuristic algorithm for solving the three-dimensional (3D) off-lattice protein folding problem. Based on a physical model, the problem is converted from a nonlinear constraint-satisfied problem to an unconstrained optimization problem which can be solved by the well-known gradient method. To improve the efficiency of our algorithm, a strategy was introduced to generate initial configuration. Computational results showed that this algorithm could find states with lower energy than previously proposed ground states obtained by nPERM algorithm for all chains with length ranging from 13 to 55.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Conformation des protéines
/
Algorithmes
/
Simulation numérique
/
Données de séquences moléculaires
/
Protéines
/
Modèles moléculaires
/
Chimie
/
Séquence d'acides aminés
/
Pliage des protéines
/
Analyse de séquence de protéine
Type d'étude:
Étude pronostique
langue:
Anglais
Texte intégral:
Journal of Zhejiang University. Science. B
Année:
2006
Type:
Article
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