In vitro study of immunosuppressive effect of apoptotic cells / 浙江大学学报(英文版)(B辑:生物医学和生物技术)
Journal of Zhejiang University. Science. B
; (12): 919-925, 2005.
Article
Dans En
| WPRIM
| ID: wpr-263276
Responsable en Bibliothèque :
WPRO
ABSTRACT
Recent studies revealed that apoptotic cells are actively involved in immunosuppression and anti-inflammation. After being phagocytosed by macrophages, apoptotic cells can actively regulate cytokines secretion from lipopolysaccharide (LPS)-stimulated macrophages, in which the secretion of immunosuppressive cytokines such as interleukin-10 (IL-10) is increased while the pro-inflammatory cytokines such as tumor necrosis factor-alpha (TNFa), interleukin-1beta (IL-1b) and leukin-8 (IL-8) are suppressed. In this paper, we first present evidence that phagocytosed apoptotic cells regulate cytokine secretion of LPS-stimulated macrophages, but also inhibit the activation of T lymphocytes stimulated by ConA. These data suggest that apoptotic cells can alter the biological behavior of macrophages which gain immunosuppressive property.
Texte intégral:
1
Indice:
WPRIM
Sujet Principal:
Phagocytose
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Pharmacologie
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Techniques in vitro
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Activation des lymphocytes
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Lymphocytes T
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Récepteurs à l'interleukine-2
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Transduction du signal
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Antigènes de différenciation des lymphocytes T
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Antigènes CD
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Lipopolysaccharides
Limites du sujet:
Animals
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Female
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Humans
langue:
En
Texte intégral:
Journal of Zhejiang University. Science. B
Année:
2005
Type:
Article