Opinion of colon-targeting delivery about rhubarb extract as a purgative / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 72-74, 2002.
Article
Dans Chinois
| WPRIM
| ID: wpr-263638
ABSTRACT
<p><b>OBJECTIVE</b>To elucidate that rhubarb extract as a purgative should be delivered to colon from a pharmaceutical point of view.</p><p><b>METHOD</b>Effects of anthranoids and free anthraquinones as purgatives on the colon motility and transit time, the absorption in vivo, and the loss in the processes of extraction, concentration and dryness were reviewed, based on the recent 60 years pharmacological, pharmaceutical and clinical experimental studies at home and abroad.</p><p><b>RESULT AND CONCLUSION</b>Free anthraquinones in rhubarb extract should be regarded as purgative principles. Close attention should be paid to the loss of free anthraquinones not only in the processes of extraction, concentration and dryness, but also in the process of transit in the upper gastrointestinal tract. Colon-targeting delivery of rhubarb extract, as a purgative, may prevent absorption of free anthraquinones in the upper gastrointestinal tract, thus improving clinical effects and lowering dosage.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Rheum
/
Médicaments issus de plantes chinoises
/
Pharmacocinétique
/
Cathartiques
/
Chimie
/
Anthraquinones
/
Systèmes de délivrance de médicaments
/
Côlon
/
Absorption intestinale
/
Métabolisme
Limites du sujet:
Animaux
/
Humains
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2002
Type:
Article
Documents relatifs à ce sujet
MEDLINE
...
LILACS
LIS