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A linkage between beta-fibrinogen gene -148C/T polymorphism and cerebral infarction / 中华医学遗传学杂志
Chinese Journal of Medical Genetics ; (6): 202-204, 2006.
Article Dans Chinois | WPRIM | ID: wpr-263817
ABSTRACT
<p><b>OBJECTIVE</b>To study the linkage between -148C/T polymorphism of beta-fibrinogen gene and plasma fibrinogen levels in patients with acute cerebral infarction.</p><p><b>METHODS</b>One hundred and fifty-one patients with cerebral infarction and 101 healthy individuals were enrolled in this trial. The beta-fibrinogen gene -148C/T polymorphism was analyzed by PCR-restriction fragment length polymorphism, and plasma fibrinogen levels were obtained from prothrombin time assay.</p><p><b>RESULTS</b>Plasma fibrinogen levels of patients were significantly higher than those of controls (P<0.01). In both groups, T allele carriers had higher plasma fibrinogen levels than other those did (P<0.01); and the fibrinogen level difference was still significant if both groups was based on their sex (P<0.05). Divided by age, each group of the study cases has significant difference between two genotypes (P<0.05). T -148 allele frequency of the middle age case in study group was higher than that in control group (P<0.05).</p><p><b>CONCLUSION</b>High plasma fibrinogen level is a risk factor to cerebral infarction. Plasma fibrinogen level is affected by -148C/T polymorphism of beta-fibrinogen gene. With or without other risk factors and environmental factors affecting, T allele increases plasma fibrinogen level and may be a heritable risk factor to cerebral infarction.</p>
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Fibrinogène / Infarctus cérébral / Prédisposition génétique à une maladie / Accident vasculaire cérébral / Asiatiques / Allèles / Génétique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Medical Genetics Année: 2006 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Polymorphisme génétique / Fibrinogène / Infarctus cérébral / Prédisposition génétique à une maladie / Accident vasculaire cérébral / Asiatiques / Allèles / Génétique Limites du sujet: Adulte / Adulte très âgé / Aged80 / Femelle / Humains / Mâle langue: Chinois Texte intégral: Chinese Journal of Medical Genetics Année: 2006 Type: Article