Expression of Ras Oncogene in the Intracpithelial Neoplasia and Carcinoma of the Uterine Cervix / 대한부인종양콜포스코피학회잡지
Korean Journal of Gynecologic Oncology and Colposcopy
;
: 217-225, 1996.
Article
Dans Coréen
| WPRIM
| ID: wpr-26415
ABSTRACT
Cellular oncogenes are expressed as an intrinsic part of the transformed or neoplastic phenotype. More than 60 of the known cellular oncogenes play a specific role in normal cellular development and differentiation. To examine the correlation between ras oncogene expression and the development of cervical cancer, this study investigated the reactivity of cervical intraepithelial neoplasia(CIN) and carcinoma of the uterine cervix by using anti-ras P21 mouse monoclonal antibody. The expression of ras oncogene significantly increased with the grade of malignancy from 11% in severe dysplasia, 30% in carcinoma in situ, 43% in microinvasive carcinoma, to 53% in invasive cancer. The expression of ras oncogene was not correlated with histologic type, tumor size, and nodal status of cervical cancer. It was concluded that expression of ras oncogene is related to early phase of carcinogenesis and tumor invasion of carcinoma of the uterine cervix.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Oncogènes
/
Phénotype
/
Épithélioma in situ
/
Tumeurs du col de l'utérus
/
Col de l'utérus
/
Gènes ras
/
Carcinogenèse
Limites du sujet:
Animaux
langue:
Coréen
Texte intégral:
Korean Journal of Gynecologic Oncology and Colposcopy
Année:
1996
Type:
Article
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