Novel Association of Killer Cell Immunoglobulin-like Receptor Genes with EBV-infectious Diseases in Children / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences
;
(12): 303-307, 2015.
Article
Dans Anglais
| WPRIM
| ID: wpr-264584
ABSTRACT
Killer cell immunoglobulin-like receptors (KIRs) which are mainly expressed on natural killer (NK) cells are implicated in many virus infections. However, it is unclear whether or not KIRs are associated with susceptibility to Epstein-Barr virus (EBV) infection related diseases. Therefore, the purpose of our study was to investigate possible correlation between polymorphisms of KIR genes and infectious mononucleosis (IM)/EBV-associated hemophagocytic lymphohistiocytosis (EBV-HLH). The polymorphisms of KIR genes were detected by polymerase chain reaction with sequence-specific primers (PCR-SSP). The results would contribute to clarify the association of KIRs with EBV induced diseases, and provide new insights into the role of NK cells and innate immune response against viral infections and/or subsequent progression.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Physiologie
/
Polymorphisme génétique
/
Virologie
/
Cellules tueuses naturelles
/
Études cas-témoins
/
Chine
/
Réaction de polymérisation en chaîne
/
Herpèsvirus humain de type 4
/
Évolution de la maladie
/
Allergie et immunologie
Type d'étude:
Étude observationnelle
/
Facteurs de risque
Limites du sujet:
Enfant
/
Enfant d'âge préscolaire
/
Femelle
/
Humains
/
Mâle
Pays comme sujet:
Asie
langue:
Anglais
Texte intégral:
Biomedical and Environmental Sciences
Année:
2015
Type:
Article
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