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Protective effects of shikonin on brain injury induced by carbon ion beam irradiation in mice / 生物医学与环境科学(英文)
Biomedical and Environmental Sciences ; (12): 148-151, 2015.
Article Dans Anglais | WPRIM | ID: wpr-264607
ABSTRACT
Radiation encephalopathy is the main complication of cranial radiotherapy. It can cause necrosis of brain tissue and cognitive dysfunction. Our previous work had proved that a natural antioxidant shikonin possessed protective effect on cerebral ischemic injury. Here we investigated the effects of shikonin on carbon ion beam induced radiation brain injury in mice. Pretreatment with shikonin significantly increased the SOD and CAT activities and the ratio of GSH/GSSG in mouse brain tissues compared with irradiated group (P<0.01), while obviously reduced the MDA and PCO contents and the ROS levels derived from of the brain mitochondria. The shikonin also noticeably improved the spatial memory deficits caused by carbon ion beam irradiation. All results demonstrated that shikonin could improve the irradiated brain injury which might resulted from its modulation effects on the oxidative stress induced by the 12C6+ ion beam.
Sujets)
Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Lésions radiques expérimentales / Radioprotecteurs / Superoxide dismutase / Lésions encéphaliques / Catalase / Répartition aléatoire / Naphtoquinones / Organismes exempts d&apos;organismes pathogènes spécifiques / Carbonylation des protéines Limites du sujet: Animaux langue: Anglais Texte intégral: Biomedical and Environmental Sciences Année: 2015 Type: Article

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Texte intégral: Disponible Indice: WPRIM (Pacifique occidental) Sujet Principal: Pharmacologie / Lésions radiques expérimentales / Radioprotecteurs / Superoxide dismutase / Lésions encéphaliques / Catalase / Répartition aléatoire / Naphtoquinones / Organismes exempts d&apos;organismes pathogènes spécifiques / Carbonylation des protéines Limites du sujet: Animaux langue: Anglais Texte intégral: Biomedical and Environmental Sciences Année: 2015 Type: Article