Intersectin 1: a molecular linker in the central nervous system / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 401-405, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-264649
ABSTRACT
Down syndrome (DS) is the most common cause of cognitive impairment associated with a congenital chromosomal abnormality, trisomy of chromosome 21. Mental retardation and congenital heart defects are key features of DS. All DS individuals develop early-onset Alzheimer's disease-like neuropathology. Intersectin 1 gene is localized on human chromosome 21, the critical region of DS, and it has higher expression in the brain of DS patients than in normal individuals. So fully understanding functions of intersectin 1 is critical for revealing the pathogenesis of DS. Intersectin 1 protein has two isoforms intersectin 1-L and intersectin 1-S. This review will focus on the distribution, expression characters and functions of intersectin 1 in the central nervous system.
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Chromosomes humains de la paire 21
/
Système nerveux central
/
Biologie cellulaire
/
Protéines adaptatrices du transport vésiculaire
/
Génétique
/
Troubles mentaux
/
Métabolisme
/
Neurones
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
/
Humains
langue:
Anglais
Texte intégral:
Neuroscience Bulletin
Année:
2008
Type:
Article
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