Changes of serum adrenocorticotropic hormone and cortisol levels during sleep seizures / 神经科学通报·英文版
Neuroscience Bulletin
;
(6): 84-88, 2008.
Article
Dans Anglais
| WPRIM
| ID: wpr-264692
ABSTRACT
<p><b>OBJECTIVE</b>Measuring the serum concentrations of adrenocorticotropic hormone (ACTH) and cortisol in epileptic seizures during sleep to investigate their link to the EEG changes.</p><p><b>METHODS</b>Pre-surgical evaluation was performed by video-EEG monitoring using 24 channel recording. Thirty six epilepsy patients could be attributed to two groups 28 patients had spontaneous seizures, and the other 8 patients whose seizures were induced by bemegride. Another 11 persons with confirmed psychogenic non-epileptic seizures (PNES) served as control group. Blood samples were obtained at five points wake (0800 a.m.), sleep (0000 a.m.), and shortly before, during and after an epileptic seizure. The serum ACTH and cortisol were measured and analyzed by chemiluminescent immunoassay.</p><p><b>RESULTS</b>The levels of ACTH and cortisol in serum underwent significant changes declining below the average sleep-level shortly before seizures, increasing during seizures, and far above the average wake-level after seizures (P < 0.001). Such changes did not occur in the control group (P > 0.05). The ACTH and cortisol levels had no significant difference between spontaneous group and bemegride-induced group (P > 0.05).</p><p><b>CONCLUSION</b>The serum concentrations of ACTH and cortisol during sleep seizures are linked with pre-ictal and ictal EEG changes in epilepsy patients.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Pharmacologie
/
Physiologie
/
Axe hypophyso-surrénalien
/
Troubles de la veille et du sommeil
/
Vigilance
/
Bémégride
/
Sang
/
Potentiels d'action
/
Hydrocortisone
/
Marqueurs biologiques
Limites du sujet:
Adolescent
/
Adulte
/
Humains
langue:
Anglais
Texte intégral:
Neuroscience Bulletin
Année:
2008
Type:
Article
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