Studies on pharmacokinetics of artemether patch in mice / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1459-1462, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-264855
ABSTRACT
<p><b>OBJECTIVE</b>To establish a HPLC-MS-MS determination method of artemether (ARM) and active derivatives DHA, and compare the pharmacokinetic parameters of ARM after transdermal and oral administration.</p><p><b>METHOD</b>The mice were divided two groups (transdermal and oral) by parallel design. ARM and active derivatives DHA in plasma of mice at different sampling time were determined. The pharmacokinetic parameters were calculated by DAS 2.0 and by statistic analysis.</p><p><b>RESULT</b>compare oral administration, the pharmacokinetic parameters of ARM after transdermal, Cmax Tmax , AUC(0-t) MRT, had significant difference (P < 0.05).</p><p><b>CONCLUSION</b>The artemether patch has long-releasing property.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Sang
/
Administration par voie cutanée
/
Calibrage
/
Médicaments issus de plantes chinoises
/
Pharmacocinétique
/
Administration par voie orale
/
Chromatographie en phase liquide à haute performance
/
Sensibilité et spécificité
/
Artémisinines
/
Spectrométrie de masse en tandem
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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