Experimental study on effect and mechanism of soybean protease inhibitor on endotoxin-induced acute lung injury / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1451-1454, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-264857
ABSTRACT
<p><b>OBJECTIVE</b>To study the protective effect of soybean protease inhibitor on LPS-induced lung injury in rats.</p><p><b>METHOD</b>Fifty male SD rats were randomly divided in five groups, 10 rats in each group as sham-operation group, model control group, positive medicine group, and high, moderate SBTI groups. Except the sham-group, other groups were induced by intratracheal instillation of LPS with a dose of 6 mg x kg(-1). All rats were given drug throughout intraperitoneal injection except the model controlled group, the positive medicine group was given PMSF with a dose of 50 mg x kg(-1), the high dose group of SBTI was given SBTI with a dose of 100 mg x kg(-1), a dose of the moderate group is 50 mg x kg(-1). We examined all rats in seven days. Index exam cell quantity, activity of neutrophilic granulocyte released elastic protease proteins in BALF, histopathological examination and so on.</p><p><b>RESULT</b>Soybean protease inhibitor can level down the level of total protein, cell quantity, PMN percent, activity of neutrophilic granulocyte in BALF. SBTI level down the content of NF-kappa B in nucleoprotein, while increase the content of I kappa B alpha in plasmoprotein.</p><p><b>CONCLUSION</b>SBTI is useful in protecting experimental pulmonary injury induced by LPS in rats.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Anatomopathologie
/
Pharmacologie
/
Glycine max
/
Chimie
/
Inhibiteurs trypsiques
/
Protéines I-kappa B
/
Traitement médicamenteux
/
Endotoxines
/
Facteur de transcription RelA
/
Toxicité
Type d'étude:
Étude pronostique
Limites du sujet:
Animaux
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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