Determination of plasma protein binding rate of methyl protodioscin with ultrafiltration / 中国中药杂志
China Journal of Chinese Materia Medica
;
(24): 1291-1294, 2008.
Article
Dans Chinois
| WPRIM
| ID: wpr-264920
ABSTRACT
<p><b>OBJECTIVE</b>To study the plasma protein binding rate of methyl protodioscin.</p><p><b>METHOD</b>The ultrafiltration was employed to determine the plasma protein binding rate of methyl protodioscin. The plasma concentrations of methyl protodioscin were measured by HPLC-MS-MS.</p><p><b>RESULT</b>The plasma protein binding rate of methyl protodioscin with rat plasma at the concentration of 20.0, 100 and 200 microg x mL(-1) were (94.6 +/- 0.16)%, (91.6 +/- 0.35)% and (86.10 +/- 0.60)%, respectively, while the plasma protein binding rate of methyl protodioscin with normal human plasma at the above concentrations were (82.11 +/- 5.12)%, (84.54 +/- 0.32)% and (88.52 +/- 1.02)%, respectively.</p><p><b>CONCLUSION</b>The binding rate of methyl protodioscin with plasma protein is high.</p>
Texte intégral:
Disponible
Indice:
WPRIM (Pacifique occidental)
Sujet Principal:
Liaison aux protéines
/
Saponines
/
Calibrage
/
Protéines du sang
/
Ultrafiltration
/
Chromatographie en phase liquide à haute performance
/
Sensibilité et spécificité
/
Diosgénine
/
Spectrométrie de masse en tandem
/
Métabolisme
Type d'étude:
Etude diagnostique
Limites du sujet:
Animaux
/
Femelle
/
Humains
/
Mâle
langue:
Chinois
Texte intégral:
China Journal of Chinese Materia Medica
Année:
2008
Type:
Article
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