A study on biomarkers of styrene / 中华劳动卫生职业病杂志

ABSTRACT

<p><b>OBJECTIVE</b>To study the biomarkers of styrene and to provide theoretical basis for bio-monitoring of styrene.</p><p><b>METHODS</b>Urinary mandalic acid (MA), phenylglyoxalic acid (PGA) and mercapturic acid (MUA) of styrene were examined by high performance liquid chromatography (HPLC).</p><p><b>RESULTS</b>The correlation regression equations between exposure dose and MA, PGA and MUA level in morning urinary samples were ŷ = 2.58x + 70.82; ŷ = 1.66x + 37.42; ŷ = 0.05x + 0.55 respectively. The correlation regression equations between exposure dose and MA, PGA and MUA level in post-shift urinary samples were ŷ = 1.85x + 89.02; ŷ = 1.33x + 4.32; ŷ = 0.04x + 0.68 respectively. All showed close dose-response relationship.</p><p><b>CONCLUSIONS</b>The level of MA, PGA and MUA in morning or post-shift urinary samples may be used as bio-monitoring indexes of styrene.</p>